Intra-articular injection of human synovium-derived mesenchymal stem cells in beagles with surgery-induced osteoarthritis

Articular Cartilage Regeneration Using Intra-articular Injection of Allogeneic Synovium-derived Mesenchymal Stem Cells in A Canine Model

Intra-articular injection of autologous mesenchymal stem cells in six patients with knee osteoarthritis.

BACKGROUND Osteoarthritis (OA) is a progressive disorder of the joints caused by gradual loss of articular cartilage, which naturally possesses a limited regenerative capacity. In the present study, the potential of intra-articular injection of mesenchymal stem cells (MSCs) has been evaluated in six osteoarthritic patients. METHODS Six female volunteers, average age of 54.56 years, with radio...

Regenerative Capacity of Synovium-Derived Mesenchymal Stem Cells into Rabbit Partial-Thickness Chondral Defect through Intra-articular Injection

INTRO DUCTIO N Damage in articular cartilage has limited possibility of spontaneous healing, and may progress to osteoarthritis which may be continued during the rest of life time with further deterioration. Synovium-derived stem cells (SDSCs) are known to have capacities for proliferation and chondrogenic differentiation; therefore they have possibilit ies to be used as a cell source for carti...

Intra-Articular Injection of Synovium-Derived Mesenchymal Stem Cells with Hyaluronic Acid Can Repair Articular Cartilage Defects in a Canine Model

Objective: The purpose of this study was to evaluate effectiveness of intra-articular injection of synovium-derived mesenchymal stem cells (SMSCs) and hyaluronic acid (HA) for the treatment of articular cartilage defects in a canine model. Methods: Forty-eight knees of 24 beagle dogs were randomly assigned to 16 groups (n=3) according to both the number of injected SMSCs (0.5×105 cells, 5×106 c...

Effects of intra-articular injection of mesenchymal stem cells associated with platelet-rich plasma in a rabbit model of osteoarthritis.

The current study aims to evaluate the macroscopic and histological effects of autologous mesenchymal stem cells (MSC) and platelet-rich plasma on knee articular cartilage regeneration in an experimental model of osteoarthritis. Twenty-four rabbits were randomly divided into four groups: control group, platelet-rich plasma group, autologous MSC undifferentiated group, and autologous MSC differe...